Genome Guardian
COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive using an astounding array of turrets, perks, mutations and powers.
Languages: English
Screenshots
About this game
COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss.
Research permanent upgrades to survive a variety of microbes across 6 game modes, each with multiple "depths".
Pair DNA nucleotides Adenine (rapid fire), Cytosine (precision), Guanine (spread), Thymine (explosive) to discover wild hybrid bioweapons!
* Bomb + Shotgun combines explosives with spread to create Blast Shotgun!
* Bomb + Bomb doubles down on explosive power to make Bazooka!
* Blast Shotgun + Shotgun forms the all-powerful Flak Cannon!
* 49 Turrets with unique strengths and functions
* 96 Perks to mix and match that drastically change how you play
* 75 Weapon & Turret Mods that can turn shots into sticky laser mines or bouncing fireballs
* 64 Mutations alter the challenges you face each run
* 20-minute Runs that can be continued in Endless Mode
* 75 Bassy Electronic Tunes that adapt to the current mood & intensity
* Cosmetics like spider legs and tank tread
* Accessibility Settings for color blindness, motion sickness, and even arachnophobia!
Prices by country
Cheapest today: 🇨🇱 Chile, $6.94. That is 49% below the typical price across eShops today. Lowest since October 2026: $4.16 in 🇨🇱 Chile on Oct 3, 2026.
| Country | Price |
|---|---|
| Chile | $6.94 |
| Brazil | $7.13 |
| Mexico | $7.51 |
| Peru | $7.99 |
| Colombia | $9.26 |
| New Zealand | $11.16 |
| United States | $11.99 |
| Canada | $12.05 |
| Poland | $12.29 |
| Australia | $12.63 |
| South Africa | $13.13 |
| Austria | $13.51 |
| Belgium | $13.51 |
| Bulgaria | $13.51 |
| Cyprus | $13.51 |
| Germany | $13.51 |
| Estonia | $13.51 |
| Spain | $13.51 |
| Finland | $13.51 |
| France | $13.51 |
| Greece | $13.51 |
| Croatia | $13.51 |
| Hungary | $13.51 |
| Ireland | $13.51 |
| Italy | $13.51 |
| Lithuania | $13.51 |
| Luxembourg | $13.51 |
| Latvia | $13.51 |
| Malta | $13.51 |
| Netherlands | $13.51 |
| Portugal | $13.51 |
| Romania | $13.51 |
| Slovenia | $13.51 |
| Slovakia | $13.51 |
| Sweden | $13.56 |
| Denmark | $13.57 |
| Czechia | $13.86 |
| Norway | $14.30 |
| United Kingdom | $14.57 |
| Switzerland | $14.72 |
Click a country to see how to buy there; new to buying abroad? Here is how it works. Prices are as each eShop lists them: VAT included where the eShop includes it, US prices before sales tax, and for Canada we add the 5% federal tax Nintendo leaves out · fetched up to 2026-11-05 02:39 UTC.
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